S7 E6: Weight Regain with GLP1ra; Orforglipron; Ivermectin vs Permethrin Artwork

NB Hot Topics Podcast

The Hot Topics podcast from NB Medical brings you the latest in general practice current affairs, reviews the latest research relevant to primary care, explores interesting and important topics in-depth, and looks at cutting edge medicine.

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NB Hot Topics Podcast

S7 E6: Weight Regain with GLP1ra; Orforglipron; Ivermectin vs Permethrin

January 16, 2026 • NB Medical Education • Season 7 • Episode 6

Welcome to the Hot Topics podcast from NB Medical with Dr Neal Tucker. In this episode, we have three new and interesting research papers to look at.

First, hitting the headlines this week, weight regain after cessation of GLP1 receptor agonists. Not a surprise, perhaps, but how fast does the weight come back, can anything be done to prevent it, and what are the implications for patients and the NHS?

Second, orforglipron - the new GLP1ra on the block and an oral treatment. Can it help weight loss and improvement in cardiometabolic markers in patients with obesity and type 2 diabetes?

Finally, which is better for treating scabies - permethrin or oral ivermectin? Would a tablet be an easier option, or is it just not as good?

References

BMJ Weight regain after cessation of weight loss medications

BMJ Editorial

BMJ Opinion

BMJ Side Effects of GLP1ras

NEJM Orforglipron RCT in obesity

Lancet Orforglipron RCT in obesity and T2DM

BMJ Scabies treatment - ivermectin or permethrin?

PCDS Scabies guideline

BAD Scabies guideline